Dose intensity
Dose intensity is the amount of drug given per unit time, for example mg per week. Changing the interval while keeping dose intensity constant preserves the average concentration but changes the peak and the trough.
Definition
Dose intensity is the dose delivered per unit time, for example mg per week. Relative dose intensity is the dose intensity actually delivered divided by the planned one, and is used to describe delays and dose reductions.
Constant dose intensity
If the dose is multiplied by the same factor as the dosing interval (for example 240 mg every 2 weeks and 480 mg every 4 weeks), the dose intensity is the same. For linear PK the average concentration at steady state is also the same, since it is the dose rate divided by clearance. A longer interval raises Cmax and lowers Ctrough.
On this site
The tarlatamab analysis compares regimens at constant dose intensity and shows that the direction is the same across the range of the published fixed effects: the average is preserved, the peak rises and the trough falls. It asks how far matching the average alone can set an interval. The summary-value analysis asks what the published values determine.
Frequently asked questions
Does the same dose intensity mean the same effect?
It means the same average exposure for linear PK, but not the same peak or trough, and whether the effect is the same depends on the exposure–response relationship.
What is relative dose intensity?
The dose intensity actually delivered divided by the planned dose intensity, often expressed as a percentage.