タルラタマブの投与間隔を、平均曝露だけで決められるか
公開PopPKの個体間変動シミュレーション、有効性の曝露反応、時期別CRS、維持曝露を分けて検討する。平均曝露を合わせてもピークとトラフは保存されないことと、公開情報による判断の限界を示す。
Daiki Kumakura
I am a mathematical biologist and a bioinformatics researcher in the pharmaceutical industry. I received my Ph.D. in Life Science from Hokkaido University in March 2025.
I study biological dynamics using mathematical models and data analysis, with an interest in pharmacometrics and systems biology.
Recent writing
When does individual information improve PK/PD prediction?
A reanalysis of measured warfarin PK/PCA data: effect delay, subject-separated prediction, and the limits of using additional PK measurements.
Do early tumor measurements improve prediction of subsequent survival?
A patient-separated landmark analysis of public colorectal cancer data, including calibration, censoring, uncertainty and temporal-integrity sensitivity.