I am a mathematical biologist and a bioinformatics researcher in the pharmaceutical industry. I received my Ph.D. in Life Science from Hokkaido University in March 2025.
I study biological dynamics using mathematical models and data analysis, with an interest in pharmacometrics and systems biology.
Hill fits, conditional profiles and technical redo comparisons distinguish usable transitions from unidentified EC50 values in a selected three-drug, six-cell-line dataset. Technical precision is not biological reproducibility.
A fixed-effect plasma/PBMC subsystem from a published clinical model is implemented independently. Equal doses give equal plasma AUC, while PBMC AUC differences are determined by a categorical formation-clearance assumption. Constant-formation and tail scenarios clarify limits; no tumor, clinical benefit, safety or regimen recommendation is inferred.
A source-based examination of catalytic motifs, structural metrics, sequence ensembles and denominators in enzyme design. Reported counts are recalculated; no model inference or enzyme experiments were performed.