Physiologically based pharmacokinetics (PBPK)
PBPK represents drug movement through tissues using physiology and drug-specific properties.
PBPK represents drug movement through tissues using physiology and drug-specific properties (FDA. Physiologically Based Pharmacokinetic Analyses: Format and Content. 2018.).
For a perfusion-limited tissue with an equilibrium tissue-to-blood partition coefficient Kp, the amount balance is dA/dt = Q × (Cin − Ct/Kp) − elimination, where Q is blood flow, Cin is inlet blood concentration and Ct is tissue concentration. Inputs may include organ volumes, partitioning and enzyme kinetics. A drug interaction prediction should be tested against clinical data relevant to the affected pathway where available.