Toxicokinetics (TK)
Toxicokinetics measures systemic exposure in toxicity studies and relates it to dose, duration and observed findings.
Toxicokinetics measures systemic exposure in toxicity studies and relates it to dose, duration and observed findings (ICH. S3A: The Assessment of Systemic Exposure in Toxicity Studies. 1994.).
Compare AUC and Cmax by dose, sex and study day, keeping the sampling window and analyte consistent. If doubling the dose triples AUC, dose and exposure no longer scale together over that interval. Repeated measurements can distinguish an early exposure pattern from one that emerges during dosing. The pattern alone cannot establish the cause of nonlinearity.