Effect compartment models
An effect compartment represents a delay between plasma concentration and the concentration driving response.
An effect compartment represents a delay between plasma concentration and the concentration driving response (FDA. Exposure–Response Relationships: Study Design, Data Analysis, and Regulatory Applications. 2003.).
The effect-site concentration Ce follows dCe/dt = ke0 × (Cp − Ce), where Cp is plasma concentration and ke0 has units of inverse time. The equilibration half-life is ln(2)/ke0. With ke0 = 0.5 h⁻¹, Ce closes half the gap to a constant Cp in about 1.39 h. Ce is usually latent and may differ from measured tissue concentration.