PK accumulation ratio
An accumulation ratio compares the same exposure metric after repeated dosing and after the first dose.
Frequently asked questions
How much does a drug accumulate if the interval equals its half-life?
For linear one-compartment IV bolus dosing, the steady-state to first-dose peak ratio is 1/(1 − exp(−kτ)). It equals 2 when the interval τ equals the half-life. Oral and multicompartment models can give different ratios.